Since a relatively large amount of water for irrigation of vegetables is requied and conventional water resources in Iran is limited, it is necessary to investigate the application of unconventional water for irrigation of plants. Irrigation water and soil salinity have a major impact on crop yield loss. In many areas the high of salinity groundwater causes soil salinity and depress on plant performance. In these areas generaly the only available water is saline groundwater and wastewater. It is important to examine, the impact of wastewater on the soil salinity and plant performance to determine appropriate management for sustainable agriculture. This study was conducted in three separate completely randomized design. Experiment was conducted in the greenhouse of Isfahan University of Technology. A total of 54 pots for cucumber, radish and lettuce were prepared.The irrigation treatments included: 100% wastewater, 75% wastewater+25% groundwater, 50% wastewater+50% groundwater, 25% wastewater+75% groundwater, 100% groundwater and 100% tap water. The level of salinities were consisted: 1, 2, 2.5, 3.5, 4.5 and 5 dS/m. The results showed that all plants have highest and lowest fresh and dry weight of shoot and root dt the salinity 4.5 and 1, respectively. The general trend in all plants for fresh and dry weight decreased with increasing in salinity levels. Cucumber and lettuce plants had the highest production with using 25% saline groundwater but with increasing salinity significantly reduced performance in all three plants. Keywords : wastewater, salinity, irrigation, cucumber, radish, lettuce.