The present study was conducted to evaluate the effect of different levels of dried tomato pomace (DTP) on growth performance, rumen fermentation and health of Holstein calves. Experiment was carried out based on a completely-randomized design with 3 treatment groups including 10 individual pens per each dietary treatment (5 male and 5 female Holstein calves). Dietary treatments consisted of 1) pelleted starter (control group), 2) pelleted starter + 7.5% DTP, 3) pelleted starter +15% DTP. The experimental period was 70 days and all calves were weaned at day 56. Body weight and starter intake were recorded 7 days apart. Rumen fluid samples were collected via a stomach tube at 70 of the study. To evaluate blood parameters, calves were bled from the jugular vein on days 35 and 70 of experiment. Statistical analysis showed that there was significant difference in daily starter intake between experimental groups (p 0/01) .So that the treatment of 15% DTP of the pre-weaning and entire trial. Than other treatment. Also, the total feed intake of than the 7/5% DTP control group (P 0/05). Average daily gain Treatment was significantly pre-weaning and post-weaning was greater in the treated was 15% DTP (P 0/05). In the course of the period daily weight gain of in the treated 15% DTP was higher than the two other treatments (p 0/01). Feed efficiency had not affected by treatments (P 0/05). Apparent DM, OM and CP digestibility in diets after weaning were not affected, but the number of treatments was less than 15% DTP (P 0/05). Body measurements such as hip width, hip height, body length, wither height and heart girth were not significantly different among the treatments during pre-weaning and post weaning .The stomach size was influenced by the treatments at pre weaning, and post weaning. Stomach size for calves fed with 15% DTP was highest (p 0/01). Rumen pH was influenced by the treatments at post weaning and rumen pH was highest for the calves fed the DTP (p 0/01). Ammonia-N concentration were influenced by the treatments and was highest for the calves fed the 15% DTP (P=0/05). Rumen fluid in calves consuming 15% DTP had concentrations of acetate on day 70 (P 0.05), also Butyrate levels were also higher in the control than in the other two treatments (P 0/01). Calves fed 15 % DTP spent more time to ruminate compared with the control group (P 0/01). In relation to health indicators, control the highest score in feces compared to other treatments had per-weaning (P 0/05). Serum cholesterol and LDL levels at 70 days was higher in the control and treated with 15% DTP showed a significant difference (P 0/05). The highest lymphocyte to neutrophil ratio was seen in calves supplemented with 15% DTP (P 0.05). In general results of this study show that the tomato pomace as a source of non-forage fiber alongside pellet feed Calves can be encouraged to further improve feed intake and fermentation rumen calves and also the immune system and improve blood lipid components. Keywords : calves, Tomato pomace, performance, Ruminal fermentation, health