This study was conducted in two separate experiments in a greenhouse at Isfahan University of Technology, Iran in 2014 in order to study the response of wheat cultivars to elevated CO2 and temperature under different salinity levels. In the first experiment, 20 wheat cultivars were evaluated under two levels of carbon dioxide (380 and 700 ?mol mol-1) and two levels of salinity (0 and 150 mM NaCl concentrations in irrigation water). In the second experiment, four wheat cultivars (Sepahan, Chamran, Marvdasht and Sorkh tokhm) that were chosen from the first experiment, differing in their response to salinity, were studied under two levels of carbon dioxide (as used in the first experiment), two levels of salinity (0 and 120 mM NaCl) and two different temperatures (average 23?C as ambient and average 27?C as increased temperature). In both experiments, treatments were arranged as factorial in a randomized complete block design. The results of the first experiment showed that salinity decreased the concentration of potassium (K+) in shoot and roots, K+/Na+ ratio in shoot and roots, the concentration of chlorophyll and carotenoids, plant height, leaf area, root volume, shoot and root dry weight but increased the concentration of sodium (Na+) in shoot and roots. The extent of decreases in shoot dry weight due to salinity among 20 wheat cultivars ranged from 8 to 46 percent. Karaj and Marvdasht were the most tolerant and the most sensitive wheat cultivars to salinity, respectively. With an increase in air CO2 level, the concentration of K+ in shoot (exept in Sholeh, Ghods and Gasparood) and roots, K+/Na+ ratio in shoot (except in Ghods) and roots, chlorophyll and carotenoid concentrations, plant height, leaf area (except in Shariar), root volume, shoot and root dry weight were increased but the concentrations of Na+ in shoot and roots were decreased in all tested cultivars. The highest and the lowest (27 and 4 percent) increases in shoot dry weight were observed in Chamran and Sistan cultivars, respectively. In the second experiment, in which plants were harvested at physiological maturity, salinity decreased the concentration of K+ in shoot and roots, K+/Na+ ratio in shoot and roots, chlorophyll and carotenoid concentrations, plant height, grain weight per plant, shoot and root dry weight but increased Na+ concentrations in shoot and roots, proline concentration and the activities of catalase and ascobate peroxidase enzymes. Under increased level of air CO2, K+ concentrations in shoot and roots, K+/Na+ ratio in shoot and roots, chlorophyll and carotenoids concentrations, plant height, grain weight per plant, shoot and root dry weight, grain weight per plant and the activities of catalase and ascobate peroxidase were increased but proline concentration and the concentration of Na+ in shoot and roots were decreased. The extent of increases in the concentration of K+ in shoot and roots, chlorophyll concentration, plant height, leaf area, the activity of catalase and shoot and root dry matter at elevated CO2 was greater under saline than under non-saline condition. While, the positive effect of elevated CO2 on root volume, the activity of ascobate peroxidase and carotenoid concentration (only in the first experiment) was greater under non-saline condition. Regardless of salinity level and cultivar, the positive effect of elevated CO2 on plant growth was greater under elevated than under ambient temperature. At elevated compared to ambient temperature, the concentration of K+ in shoot and roots, plant height, chlorophyll concentration, grain weight per plant, plant total dry weight were decreased, while, the concentrations of Na+ in shoot and roots, proline concentration and the activities of catalase and ascobate peroxidase were increased. The results of this experiment showed that elevated concentration of air CO2 positively affected the growth of tested wheat cultivars and the extent of the these effects was dependent on cultivar, temperature and salinity level. Keywords: Wheat cultivars, Salinity, Elevated CO2, temperature, sodium, potassium, Anioxidant enzymes, carotenoids, proline