Heavy metals are environmental contaminants in industrialized societies. Over recent decades the annual worldwide release of zinc (Zn) have increased to 1,350,000 ton. Zn contaminated soils can be remediated by chemical, physical or biological techniques. phytoremediation is lowest cost technique. Plants will remediate soils with different methods. Hazardous biomass of phytoremediation could be used as a source of contamination and suitable management of these disposal materials can approach us to sustainable agriculture. Zinc deficiency appears to be the most widespread micronutrient in plants worldwide. Agronomic biofortification is one of the best methods to fight Zn deficiency that approaches by crop residue and fertilization that will increase Zn bioaccumulation in soil and plant. The purpose of this study was to investigate the use of contaminated soil residues, sewage sludge and zinc sulphate on wheat Zn uptake. At the firs part, soil sample were collected from the zinc and lead bama mine in Irankooh. Phytoextraction ability of Heliantus annus .L , Trifolium pretense .L , Thlaspi caerulescens and Amaranthus retroflexus were investigated in 8 kilogram pots. The experiment was conducted in a completely randomized design with 3 replication in a greenhouse. The result showed that Zn concentration in Thlaspi caerulescens shoot was greatest (4041 mg kg -1 ) among the plants. In the second part of this experiment, crop residues of the first part (5 ton ha -1 ), sewage sludge (5 and 10 ton ha -1 ), Zn sulphate (20 and 40 kg ha -1 ) with a control treatment without addition of Zn and also two wheat cultivar including Kavir (as a Zn inefficient cultivar) and Back Cross Rushan (as a Zn efficient cultivar) were considered. The experiment was conducted in afactorial arrangementbased on completely randomized design with 3 replication in a greenhouse. After 7 month growth, wheat yield, Zn concentration and Zn total content in roots, shoots and grains and grain protein were measured. The result showed that there was no differences between the two cultivars in grain yield and grain Zn concentration but Kavir had more root and shoot dry weight. The result of application treatments showed that the most grain yield was observed in sewage sludge treatment (10 ton ha -1 ) and Zn sulphate treatment (40 kg ha -1 ). The maximum Zn concentration in soil and grain was observed in Thlaspi caerulescens treatment (5 ton ha -1 ). KeyWord: Phytoremediation, Agronomic biofortification, Phytoextraction, Zn efficient, Zn inefficient