The selection of suitable tillage management for sustainable agriculture depended on soil, and environmental conditions of the area. For each area, the effects of different tillage methods on soil characteristics and crop yield should be study in order to be able to recommend the appropriate tillage method. The appropriate tillage method should economically increase crop yield and should have least damage to soil. In this study, a field experiment was conducted in 2013 in the city of Gonabad in Khorasan Razaviprovience using a completely randomized block split design for sorghum. The main treatments includes three tillage managements of no tillage (A 1 ), reduced tillage (A 2 ) and conventional tillage (A 3 ). The sub treatments include three crop residue managements of without crop residue (B 1 ), with 30 % crop residue (B 2 ) and with 60 % crop residue (B 3 ). For each treatment, three irrigation application levels of 50 % of the required water (C 1 ), 75 % of the required water (C 2 ) and 100 % of the required water (C 3 ) were applied. The effects of these treatments on soil infiltration, sorghum yield and water use efficiency were studied. The results showed that the effect of tillage on soil infiltration, wetted width, fresh and dry weight of plant, plant height and water use efficiency were significant, at 1 % level. The increased in depth of tillage, improved soil infiltration, fresh and dry weight of plant, plant height and water use efficiency. The crop residue had no significant effect on soil infiltration, wetted width and fresh and dry weight of plant, but had significant effect on plant height and water use efficiency, at 5 % level. The effect of irrigation levels on soil infiltration, wetted width, fresh and dry weight of plant, plant height and water use efficiency were significant, at 1 % level. The increased of irrigation level, improved soil infiltration, fresh and dry weight of plant and plant height but had inverse influence on water use efficiency and as the irrigation level increased the water use efficiency decreased significantly. The interaction effects of tillage, crop residue and irrigation levels treatments on soil infiltration, wetted width, fresh and dry weight of plant and water use efficiency were not significant. Conservation tillage, including low tillage and no tillage, increases water use efficiency, as compared to the traditional tillage. The use of tillage is recommended, because causes increase in soil infiltration, crop yield and water use efficiency. Keywords: Tillage, Crop residue, Deficit irrigation, Sorghum, Yield, water use efficiency