A pot experiment was conducted under out door condition at collage of agriculture, Isfahan University of Technology, Esfahan, Iran in order to evaluate the effects of mycorrhizal inoculation and the application of humic acid on the response of wheat plants to salinity. In this experiment the effects of inoculation with two arbuscular mycorrhizal fungi ( Funneliformis mosseae and Rhizophagus intraradices ) and the application of two humic acid levels (0 and 100 mg/l in irrigation water) were studied under three salinity levels (0, 60 and 120 mM NaCl). Treatments were arranged as factorial based on a completely randomized design with four replications. Salinity decreased the concentrations of potassium and phosphorous, the contents of chlorophyll and carotenoid, plant height, shoot and root dry weights, root volume and 1000 grain weight, number of grains per ear, number of grains per plant and grain weight per plant, while increased the concentration of sodium, the activities of antioxidant enzymes catalase, ascorbate peroxidase and peroxidase, H 2 O 2 and lipid peroxidation (MDA content). Grain yield (grain weight per plant) was reduced by 31 and 52% under 60 and 120 mM salinity treatments. Mycorrhizal inoculation and the application of humic acid increased potassium and phosphorous, biomass production, grain yield and its components, the activities of antioxidant enzymes, while decreased the concentration of sodium, H 2 O 2 and lipid peroxidation. In most cases Rh. intraradices was superior as compered to F. mosseae . Grain yield was increased by 17 and 35% as result of plant inoculation by F. mosseae and Rh. intraradices , respectively, and by 18% due to humic acid application. The highest increases in the activities of antioxidant enzymes in response to mycorrhizal inoculation and humic acid application were observed in catalase. The extent of positive effects of inoculation by mycorrhiza on plant growth and biomass production under non-applied humic acid condition was greater at saline but under humic acid application was greater at non-saline treatment. The application of humic acid had greater effects on plant growth under saline condition in plants inoculated by Rh. intraradices but under non-saline condition in non-inoculated plants. The results from this experiment showed that mycorrhizal inoculation and the application of humic acid not only stimulated the growth but also alleviated the destructive effects of salinity on wheat plants. Key words: Wheat, salinity, mycorrhizae, humic acid