A pot experiment was conducted at collage of agriculure of Isfahan University of Technology, Esfahan, Iran in order to evaluate the interactive effects of mycorrhizal inoculation and the application of salicylic acid on the response of wheat to salinity. In this experiment the effects of inoculation with two arbuscular mycorrhizal fungi ( RhizopHagus intraradices and Funneliformis mosseae ) and the foliar application of four salicylic acid concentrations (0, 60, 120 and 180 mg/l in irrigation water) were studied under three salinity levels (0, 60 and 120 mM NaCl). Treatments were arranged as factorial based on a completely randomized design with four replications. Salinity decreased mycorrhizal infection, pHospHorous and potassium concentrations, water relative content, membrane permeability, chloropHyll and carotenoid contents, plant height, root volume, shoot and root dry weights, number of spikes per plant, number of grains per spike, number of grains per plant, 1000 grain weight and grain yield (grain weight per plant), while increased the concentration of sodium and proline, the activities of antioxidant enzymes including catalase, peroxidase and ascorbate peroxidase, H2O2 and lipid peroxidation (MDA content), chloropHyll a/b and shoot/root ratios. The reductions at salinity levels of 60 and 120 mM NaCl for shoot dry weight were 23 and 41% and for grain yield (grain weight per plant) were 17 and 27%, respectively. Mycorrhizal inoculation increased pHospHorous and potassium concentrations, the activities of antioxidant enzymes and the plant growth charactristics and grain yield while decreased the concentration of sodium and proline, H2O2 and lipid peroxidation. In most cases the effects of inoculation by Gh. intraradices were greater as compared to those of G. mosseae . Inoculation by Gh. intraradices as compared to G. mosseae led to gventer increas pHospHorous concentration, potassium/ sodium ratio, the activities of peroxidase and ascorbate peroxidase, chloropHyll a content, plant height, shoot dry weight, number of grain per plant and grain weight per plant and sewallevs decreas in H2O2 content and lipid peroxidation. The increases due to inoculation by Rh. intraradices and F. mosseae were 15 and 13% for shoot dry weight and 12 and 5% for grain yield, respectively. The extents of increases in biomass and grain yield due to inoculation under non-saline condition were greater in the plants inoculated by Rh. intraradices but under severe salinity level were greater in the plants inoculated by F. mosseae . The application of 60, 120 and 180 mg/l concentrations of salicylic acid increased shoot dry weight by 10, 15 and 14% and grain yield by 8, 12 and 14%, respectively. The highest biomass and grain yields under all salinity levels were obtained in the plants sprayed by 120 mg/l salicylic acid concentration. The magnitudes of increases in biomass and grain yield due to salicylic acid foliar application were greater under non-saline than under saline conditions. The interaction between mycorrhiza and salicylic acid were not significant on biomass and grain yield and also on most of measured traits. Based on the results of this experiment, mycorrhizal inoculation and foliar application of salicylic acid improved plant growth but the extent of positive effects of these amending factors depended on the level of imposed salinity.