This experiment was conducted in Soilless Culture Research Center at the Isfahan University of Technology in 2013, using hydroponic culture. In this study the effects of ordinary and nano forms of iron chelate fertilizer were evaluated on the responses of six wheat cultivars (Line-9-shoory, Kavir, Sorkh tokhm, Chamran, Adl and Star) under four salinity levels (0, 50, 100 and 150 mM NaCl). The experiment was carried out as factorial in a randomized complete block design with three replications. Plants were harvested at vegetative and physiological maturity stages. SPAD index, plant height, root length and volume, leaf area, shoot and plant total dry weight, the concentration of potassium in shoot and roots, number of spike in plant, spike length and weight, number of grains and grain weight in spike were reduced under saline conditions. SPAD index and root volume of Chamran and Adl, shoot and plant total dry weight of Kavir, spike length and the number of spikes in plant were not negatively affected by 50 mM NaCl salinity. However, leaf yellowing intensity, root/shoot dry weight ratio, sodium concentration in shoot and roots and sodium/potassium ratio in shoot and roots were increased under saline treatments. The extent of decreases in shoot dry weight at 50, 100 and 150 mM NaCl were greater in plants harvested at physiological maturity (48, 65 and 83%, respectively) than those harvested at vegetative stage (20, 27 and 28%). Based on the average reductions in shoot dry weight under three salinity levels, cultivars Adl and Line-9-shoory at vegetative stage and Adl and Sorkh tokhm at physiological maturity stage were the least and most salt sensitive cultivars, respectively. There were significant differences among wheat cultivars in response to nano form of iron chelate. Supply of plants with the nano compared to the ordinary form of iron chelate increased shoot dry weight of cultivars Line-9-shoory, Kavir, Chamran, Adl and Star and decreased shoot dry weight of cultivar Sorkhtokhm at vegetative stage, but increased shoot dry weight of cultivars Line-9-shoory, Kavir, Sorkhtokhm and Star and decreased shoot dry weight of cultivars Chamran and Adl at physiological maturity. The ratio of root/shoot dry weight was decreased under 50 but it was increased under 100 and 150 mM NaCl as plants were supplied by the nano form of iron chelate. The results of this experiment showed that there were significant differences among wheat cultivars in response to salinity and the application of nano form of iron chelate. Key words: Wheat cultivars, Salinity, Iron chelate, Nano particles, Potassium, Sodium