In oil and gas pipelines, the use of thermodynamic inhibitors is the most common method of protecting the line from the dangers of hydrate formation. Due to the high consumption of thermodynamic inhibitors and the need to recycle it at the end of transmission lines and with the aim of achieving better performance and optimal consumption, the simultaneous use of thermodynamic and kinetic inhibitors is proposed. Accordingly, in this study, the main purpose of this study was to investigate the effect of the simultaneous presence of thermodynamic inhibitors and kinetic inhibitors on the inhibition of sour gas hydrate formation. In this study, two-component acid gas including methane and hydrogen sulfide, monoethylene glycol (concentrations of 10 and 20 wt%) was used as a thermodynamic inhibitor and polyvinyl caprolactam (0.1 and 0.2 wt%) was used as a kinetic inhibitor. First, after validating the laboratory system based on comparing the laboratory data of methane and pure water obtained from the system with the data published in scientific sources, measuring the thermodynamic equilibrium points of two-component sour gas in the presence and absence of ethylene glycol by volume method. Fixed with step heating. Laboratory data had an acceptable agreement (AAD = 0.16%) with the prediction of HWHYD software. . To design kinetic experiments for the simultaneous presence of two inhibitors of ethylene glycol and polyvinyl caprolactam, first the kinetics of methane hydrate formation in the presence of ethylene glycol with different concentrations (range 5 to 20% by weight) at the same operating point was performed. The results showed that in these tests, the displacement of the equilibrium curve due to the presence of a thermodynamic inhibitor caused the driving force applied to the system to decrease and interfere with the study of the kinetic effect. In order to solve this case, the experiments were followed with the same degree of supercooling approach. In the two-component sour gas hydrate formation tests in the presence of ethylene glycol, the target temperature for the control system is 10% and 20% by weight of ethylene glycol equal to 5, 2 and -1.3 ° C (equivalent to constant subcooling: 9.8 °C) was determined relative to laboratory equilibrium data. In experiments related to the presence of kinetic inhibitors, the results showed that the inhibitory performance decreased sharply with increasing subcooling from 9.8 °C to 12.8 °C in order to evaluate the system operation at 2 °C operating temperature. Simultaneous presence of two thermodynamic and kinetic inhibitors enhanced the inhibitory function against hydrate formation. According to the thermodynamic inhibitor mission, if the inhibitor concentration does not cause proper displacement of the hydrate fuzzy equilibrium curve (in order to cover operating conditions outside the hydrate area), the system has a high risk of hydrate formation and the higher the inhibitor concentration (induction time about 3 hours in the presence 20% ethylene glycol) The risk of hydrate formation is even higher than in the control system. In the simultaneous presence of ethylene glycol with concentrations of 20% and 0.1% PVCap, no signs of hydration were observed for 48 hours. In comparison with the presence of only 0.2% PVCap, which protected the system for more than 48 hours by considering subcooling of 9.8 °C (equivalent to 5 °C operating temperature), the simultaneous presence of two inhibitors resulted in an operating temperature of 5 °C to -1.3°C. Keywords: gas hydrate, thermodynamic inhibitor, kinetic inhibitor, Synergistic, ethylene glycol, PVCap, hydrogen sulfide, induction time