The separation of soluble materials from solutions is difficult when their concentrations are relatively small and their separation via conventional separation techniques like ultra-filtration,chromatography, distillation and solvent extraction are often inefficient and expensive. Consequently, it is necessary to develop and expand new separation methods.A promising technique is foam fractionation, which is regarded as a gentle, economical and ecological technique, has been used for the separation of proteins, mineral, organic substance, microorganisms, aromatic substances, suspended solid, surfactant, metals ions,and toxic substances in dilute solution. Foam fractionation is a type of adsorptive bubble-separation technique which requires generation of foam to carry off the objective substances.Zirconium, the material used in this study is useful in nuclear energy applications, because of its very low absorption for neutrons. This metal also has many other uses in photographic flashbulbs and surgical instruments, in production of television screens, in the removal of residual gases from electronic vacuum tubes, and as a hardening agent in alloys, especially steel. The paper and packaging industries are finding that zirconium compounds make good surface coatings because they have excellent water resistance and strength. The aim of this study is extraction and enrichment of zirconium ion from synthetic aqueous solutions by continuous foam fractionation. Effects of various operating parameters such as Nitrogen gas flow rate, and solution parameters such as initial feed concentration (Zirconium chloride), surfactant concentration (Sodium dodecyl sulfate) and initial pH of solution on recovery and enrichment of the metal were investigated. In this study, a homemade polycarbonate-foam-fractionation column was used. The height of the column was 60 cm, and the inner and outer diameters were 4.4 cm and 5 cm, respectively. The gas distributor had the pore size of 5 to 10 micrometers. The power of the feed pump was 7.55 W, and a nitrogen gas cylinder equipped with a pressure regulator and a gas flow meter provided the required gas phase. An electrical current regulator was used to change the pump flow rate. The considered ranges for parameters obtained by primarily experiments are: feed concentration (10-50 ), surfactant concentration (100-500 ), pH (5-7), and Nitrogen flow rate (0.5-1.5 ). In order to study the effect of these parameters, experiments were designed by Design-expert 9.0 (Trial version) software and RSM method, and data analysis were done by ANOVA. The obtained model by RSM method for enrichment ratio and recovery percentage is Quadratic. The R 2 coefficient for the obtained model for enrichment ratio and recovery percentage is 0.9070 and 0.9167, respectively. The optimal values of enrichment ratio and recovery percentage arrived by the model for zirconium are 7.423 and 46.898, respectively. These optimal parameters values correspond to feed concentration(29.5), surfactant concentration(306.3), pH (6.0)و and gas flow rate (1.01 ). Desirability of obtained optimal values are 0.89. Optimal values obtained for enrichment ratio and recovery percentage has conformity with actual values derived by experiments.