Pigmented Purpuric dermatoses (PPD) is a skin disorder with features such as red, brown and yellow rash bruises; that mainly seen in the lower limbs. The cause of this disease still remains unclear as well as the resistant to treatment. In this study, Due to the vagueness of the cause of the disease, the absence of a certain treatment for this disease and that it is more common in the lower limbs, in this study we design nanofibers containing a drug via electrospinning with the ability to increase the resilience of capillaries in order to eliminate the PPD disease and this web layer is also placed as an inner layer of socks. Nanofibres produced in this study were produced for first time using polyethylene oxide 8%, sodium alginate 2% and vitamin C by conventional electrospinning and core-shell electrospinning. The morphology and diameter distribution of nanofibers produced Nanofibres produced in this study were produced for first time by using polyethylene oxide 8%, sodium alginate 2% and vitamin C by conventional electrospinning and core-shell electrospinning. The morphology and diameter distribution of nanofibers produced were observed by scanning electron microscopy (SEM). Due to the hydrophobicity of polymers used in the preparation of nanofibers, glutaraldehyde vapors was used for crosslinking of the samples. Interactions between polymers and drug, confirmation of drug presence in samples and crosslinking of samples were investigated by using Fouier transform infrared spectroscopy. The release of vitamin C from samples was measured using a phosphate buffer solution and its skin absorption was measured byFranz diffiusion. Releasing vitamin C of sodium alginate and polyethenic oxide nanofibers, is 90.3% and 91.7%, respectively, with an increase in vitamin C content from 5% to 10%, respectively.The highest levels of vitamin C release from nanofibers with sodium alginate-polyethylene oxide as shells and vitamin C as core are 95%, indicating a controlled release of vitamin C from core- shell nanofibers.Regarding the application of manufactured nanofibers as the inner layer of socks, the release behavior of nanofibers was investigated under the applied stretch 0%-5%-10%-15%-20%.