Although wollastonite bioceramic possesses good bioactivity and biocompatibility but their poor mechanical strength and high degradability hinders its clinical applications. The aim of this study was to generate wollastonite scaffolds with various forsterite contents (0, 10, 15 and 20 wt.%). The scaffolds fabricated using polymeric sponge replica method and then sintered at 1300° C for 3 hours. The phase analysis and morphology of nanopowders and scaffolds were characterized using X-ray diffraction spectroscopy, transmission electron microscopy and scanning electron microscopy. Also bioactivity, biodegradability and cell response of scaffolds were investigated. The results showed that the scaffolds possessed well-interconnected porous structure with pore size in the range of 200-600 µm and porosity 65 to 78%. With increasing forsterite content, porosity percentage reduced. Also apatite formation ability and degradation rate of wollastonite decreased by incorporation of forsterite content from 0 to 20 wt.%. MTT assay showed that scaffolds with forsterite had better cell proliferation compared to pure wollastonite scaffolds. The results suggested that wollastonite/forsterite scaffolds could be more appropriate compared to pure wollastonite scaffolds for the bone regeneration. Keywords : Wollastonite; Scaffolds; Forsterite; Bioactivity; Cell response
