In this research, it is trying to magnetic nanoparticles of magnetite (Fe 3 O 4 ) with natural polymer of Quince Seed (quince seed mucilage as a natural coating, biocompatible and biodegradable) are sustained and then the ciprofloxacin drug is loaded on these nanoparticles. Then, structural, magnetic, physicochemical, colloidal stability and antibacterial properties of samples, has been investigated by using characteristic tools and various tests such as X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) analysis, Field Emission Electron Microscopy (FESEM), Vibrating Sample Magnetometer (VSM) technique, Fourier Transform Infrared (FTIR) spectroscopy, light spectroscopy instrument (UV-Vis), Dynamic Light Scattering (DLS) technique, Measurement of Specific Surface of nanoparticles technique (BET) and also Disk Diffusion Anti-Bacterial test. The results of XRD and also structural analysis of samples, demonstrates the phase of magnetite with high sincerity. The results of FE-SEM and TEM analysis demonstrate the spherical morphology and high small size (mean 13 nm) of magnetite nanoparticles. The results of DLS analyze, show the hydrodynamic diameters values between 81.9 to 119.2 nm for magnetic nanoparticles with various structures. The values of Zeta Potential for magnetic nanoparticles are between -28 to -55.2 mv that demonstrate suitable colloidal stability of nanoparticles for biological application. The results of VSM, show the high saturation magnetization of samples and also the negligible values of Coercivity and Remanence of samples demonstrate superparamagnetic property of anoparticles.
