Ion optical sensors are one of the most common sensors in chemistry. They are used for determination of various ions in aqueous and organic solutions. We report two ion optical sensors for sensitive determination of Ni(II) and Cu(II) based immobilization of Sal 2 dapte and Qsal on plasticized PVC membrane. The absorption spectra of the optode membranes in the presence of different concentration of Ni(II) , Cu(II) showed a pronounced changes of absorbance at 443 nm , 541 nm and this property was used as an analytical criteria. The effect of different parameters such as complexation pH, type of buffer,contact time and Effect of membrane composition such as type of plasticizer, amount of ionophore and NATPB as an anionic additive were investigated. Under optimal condition the membrane based Sal 2 dapte displays a linear range of 5.0×10 ?3 – 1.0×10 ?5 M with a limit of detection of 8.1×10 ?6 M for determination of Ni(II). For membrane based Qsal obtain a linear range of 1.0×10 ?4 – 6.3×10 ?7 M and detection limit of 3.4×10 ?7 M for determination of Cu(II). The response time of the optodes was about 7–12 min, depending on the concentration of Ni(II) and 5 min for Cu(II) ions. The relative standard deviation for determination of Ni(II) were 3.62? and 2.06? for 3.0×10 ?5 and 5.0×10 ?4 M (n=7) respectively and for Cu(II) were 5.34? and 4.76? for 2.0×10 ?6 and 1.0×10 ?5 M (n=7) respectively. The influence of potential interfering ions on the determination of Ni(II) and Cu(II) were studied. The selectivity of optode to Ni(II) and Cu(II) ions in acetate buffer is good and the interference of Ag + for determination of Cu(II), were removed by participated of Ag + in the presence of Cl ? ion. The sensor based Qsal could readily be regenerated with a hydrochloric acid solution (0.1 M) and was fully reversible. The sensors was applied for determination of Ni(II) and Cu(II) in real water samples.