In the first research project the poly (vinyl chloride)/TiO 2 -Bovine serum albumin (BSA) nanocomposite films were fabricated. TiO 2 nanoparticles (NPs) due to their high surface area and the presence of hydroxyl groups on their surface, tend to accumulate in the matrix of polymers and will have accumulation mode that reduses their performances. For this purpose, initially, the surface of these was modificated by a green and friendly environment molecules sech as BSA. For this purpose ultrasound waves were used. Then to ensure which the were modified, the Fourier transform infrared spectroscopy (FT-IR), Energy dispersive x-ray (EDX) and Thermal gravimetric analysis (TGA) were performed from modified TiO 2 -BSA NPs. The FT-IR was demonstrated the presence of BSA. The EDX analysis, by showing the elements like sulfur and nitrogen, demonstrated which BSA was place on the surface of TiO 2 NPs. Finally, the TGA test showed that about 14 % BSA was located on the surface of the NPs. After preparing the TiO 2 -BSANPs the PVC/TiO 2 -BSA NC films with different perecentage weight (3, 6 and 9 wt %) were fabricated. All three NC films were successfully prepared by ultrasonic waves and their properties were investigated by using techniques such as FT-IR, EDX, Field emission scanning electron microscopy (FE-SEM), X-ray diffraction, Transmission electron microscopy (TEM), Ultraviolet-visible, TGA Mechanical and contact angle tests. The results show the improvement of the optical and thermal properiese for the fabricated NC and also increases in the wetabbility behavior. At the end, the photocatalytic activity of prepared NC film, modified was evalluted, for this aim, the PVC/TiO 2 -BSA NC 6 wt% was selected and the photocatalytic test was carried out to remove the methylene blue.