The presence of inherent uncertainty in most geoscience data is reflected in estimation errors made out of these data if we employ definite logical approaches such as Boolean logic. One of the commonly used models in estimating parameters out of insufficient and uncertain data is based on fuzzy logic inference theory. Fuzzy logic inference approach is considered as a knowledge base method in which layers are weighted based on experts knowledge. Micro-seepages from hydrocarbon reservoirs can cause a number of physicochemical alterations in the overlying rocks, soils and vegetation. Some of the surficial indication of these changes can be detected through a number of multi and or hyper spectral remotely sensed data such as ASTER, ETM+ and Hyperion. In the current study, Aster and ETM + data have been used. The study area is located in the Zagros folded zone and lies between 46? 4’ to 46? 25’ longitudes and 33? 47’ to 34? 03’ latitudes at the north to northwest of Ilam province. The presence of large oil fields, appropriate geological conditions and observed hydrocarbon seepages (including both gas and light and heavy crude oils) in the Zagros folded zone has made this region suitable for testing the capabilities of spectral remote sensing methods in detecting hydrocarbon micro-seepages. In the first stage of this research, a database consisting of remotely sensed imagery data, geological and structural units and features was formed. To detect alterations assumed to be related to hydrocarbon micro-seepages, the supervised Spectral Angle Mapper (SAM) of multi-spectral hydrocarbon micro-seepage s suggested in literature. Due to the presence of various structural elements including major anticlines, northwest–southeasterly and northeast-southwesterly oriented faults, three fuzzy logic models for integrating evidential layers were created. Finally the map showing the hydrocarbon micro-seepage potential were created and used for further field control and verification. Field observations of six control points selected from fuzzy logic favorability map in the altered areas close to previously drilled exploratory wells between Ayvan and Islamabad-Gharb towns showed evidences believed to be related micro-seepage features including anticline structures (Bankul and Babagyr anticlines ), highly crushed and extensively tectonized limestone units with clear layering structures (Asmari and Pabdeh formations), abundant occurrence of iron oxides (both limonite and hematite), traces of chlorite alteration, specific vegetation (shorter shrubs and mostly dried with less coverage density) and the presence of highly enriched agricultural soils with dark brown to black color indicating abundance of organic materials.