In this work a novel fluorescent biosensor is developed, based on green carbon quantum dots (CDs). These CDs were synthesized from valerian with hydrothermal method. Here images of transmission electron microscopy and dynamic light scattering diagrams confirm synthesis quantum dots with size under 10 nm. In this work considered on applications of CDs for determination imipramine (IMI). Here fluorometric of CDs was used as sensor for measuring different concentrations of IMI. Imipramine is antidipressent medicine and valerian too using for treatment of neurological diseases. Quenching of fluorescence CDs result of connection to IMI with positive surface charge and then identified by analytical signal. The results show liner range in 1.0-200.0 ng mL -1 IMI and detection limit (DL) 0.6 ng mL -1 was accesed. For performance evaluation of sensor in real sample IMI was measured in plasma samples and acceptable results was obtained. In the following, boehmite was modified with CDs and seen that fluorescence intensity was more than before. In the presence Boh/CDs intensity for det e rmination different amount of IMI was increased and low concentrations of IMI were identified. The images of TEM were confirm that CDs are located on boehmite. Here liner range and detection limit was obtained respectively 0.5-200.0 and 0.2 ng mL -1 .
