Since the 1940, desertification caused by drastic and irregular land use change in arid and semi-arid regions of the country has posed a serious threat to the sustainability of lands and human communities. Land use changes are one of the important factors in watershed desertification and eradication of biodiversity. Therefore, we can take a step toward equilibrium with the knowledge of land use change trends to guide the ecosystem. The purpose of this study was to investigate the impact of land use changes on desertification processes in Jazmourian wetland area in southern Kerman province. The Jazmourian catchment is located in south-east of Iran and is one of the watersheds that have faced serious challenges in recent years such as wetland drying, negative aquifer balance, land use changes, increased land cultivation. Water and horticulture and the changing pattern of cultivation have been met by low consumption crops and crops with high water demand. In order to better manage the catchment, it is necessary to have in-depth knowledge of basic information such as landscaping and its application. Landsat TM and OLI satellite images (2002 and 2018) and remote sensing software and GIS were used to investigate the impact of land use change on the destruction of the Jazmourian plain. Finally, the desertification process of the area was studied by analyzing soil, vegetation, climate and wind erosion as the main criteria of the Medalus desertification model. The results of land use change map showed that during the study periods the level of rangelands, rivers and lakes decreased and the level of agricultural, garden, saline, waste and urban development areas increased. Most of the land use changes in the study area are agricultural, residential and Bayer. The results of this study show that rangelands have declined to about 1870 hectares over a 17-year period. The results showed that the study area was Key words: Land Use changes, Desertification, Medalus Model, Jazmourian, South Kerman Province