The present study was performed to evaluate the inbreeding effects and Variation in F2 Population of Some Bell Pepper Hybrids. Genetic materials included high-yielding commercial F1 hybrids of Lumus, Nirvin and Delirio with yellow, red and orange colors, respectively together with 75 plants from each of their F2 populations. Twenty morphological, physiological and biochemical traits were measured on F1 parents and each of the F2 population. For most of the traits, negative values of inbreeding was observed in F2 populations of Nirvin and Delirio. In contrast, in F2 population of Lumus, the value of inbreeding for most of the traits was positive showing better performance of F2 progenies of this population in contrast to their F1 parents, which probably makes this possible to use advanced selfed generations of Nirvin and Delirio in breeding lines to produce hybrid seeds; and using Loumus hybrid progenies in family selection and developing open pollinated cultivars. In this study, in all of the F2 populations, single plants with higher yield comparing to their F1 parents were found. Also in lomus F2 population, higher genetic and phenotypic variation was observed for most of the studied traits, which probably indicates the presence of more additive genes in this hybrid controlling the traits. The results of cluster analysis in each population divided genotypes into five groups with significant differences between the groups for different traits. Desirable genotypes in greenhouse included genotypes with high yield, blocky-shaped fruits with lower length/width ratio and with balanced vegetative/reproductive growth. The results of cluster analysis also indicated that selecting from the fifth group of progenies in F2 of Lumus, and also from the first and third groups in Nirvin F2 population and from third group of Delirio F2 population can be used to produce a population with better yield and yield components. For fruit yield of pepper, the value of heritability was obtained less than 50% indicating that selection based on this trait will not be effective. However, selection based on stem diameter, fruit number, single fruit weight, fruit width, and pericarp thickness will be useful in increasing pepper yield because of their high heritabilities. Positive and significant correlations were also observed between yield with stem diameter, fruit width, fruit weight and pericarp thickness showing the possibility of selection based on these traits to improve pepper yield. Keywords : Inbreeding, pepper, hybrid, heritability