Recent researches about couple behavior and increasing application of acid and corrosive solution in engineering studies shows a need for further studies in this research field. The effect of acid on rock especially Asmary Limestone which is used widely in oil industry, mine, and civil engineering is very important. Considering this subject that in the most pervious researches the effect of chemical in rock with variable parameters including Temperature, anisotropy, and acid concentration is neglected. In this study this subject is attempted to be investigated. In this study two different acids (HCOOH HCl) in 20 and 60°c and also in volumes of 150 and 250 gal/ft were undergone acidic erosion. Rock anisotropy which is an important parameter among rock properties is also studied. After acidic erosion the sample were experimented to determine physical, mechanical, sonic, and microscopic properties. The results show that rock resistance decreases and its porosity increases as acid solution strength increases. Acid penetration depth has indirect relationship with acid reaction rate. Penetration depth and acid effect are different in various anisotropic direction. Amount of effect on parameters is highly dependent on couple process especially simultaneous temperature and acid concentration increase that show negative effects. Acid solution stability increase as volume increase and porosity increase rate also increases according to the observation. It last at most 2 hours for the reaction to equalize. In this study with more rigorous investigation on stress-strain curve of acidized rock sample it was found that the curve slope after acidizing had differed with acid penetration depth. Stress-strain curve slope was smaller at the beginning of loading and with getting closer to rock ultimate resistance, the curve slope gets closer to sound rock stress-strain curve slope. Effect of acidizing on limestone fracture toughness is different according to anisotropy.