An annular FGM plate, resting on a nonlinear elastic foundation under a transverse uniform loading and a transverse non-uniform temperature, is considered. The mechanical and thermal properties of the FGM plate are assumed to be graded in the thickness direction according to a simple power law distribution in terms of the volume fractions of the constituents. The mathematical modeling of the plate and the resulting nonlinear governing equations of equilibrium are derived based on the first-order shear deformation theory (FSDT) in conjunction with nonlinear von Karman assumptions. A polynomial-based differential quadrature method is used as a simple but powerful numerical technique to discretize the nonlinear governing equations and to implement the boundary conditions. Finally, the effects of certain parameters, such as nonlinear foundations stiffness, volume fraction index, and temperature, on the axisymmetric large deflection response of the FGM plate are obtained and discussed in detail. Keywords: Large deflection; Functionally graded; Nonlinear elastic foundation; Thermomechanical loading; Differential quadrature method.