Liver diseases are one of the main risks to human health. Although liver tralantation is a common and effective treatment for acute liver paints, donor shortages, the high cost of tralantation. Tissue engineering using biomaterial scaffolds is a way to regenerate living tissue to replace lost or damaged organs. In order to achieve this goal, an extracellular matrix (ECM) is required for cells to adhere, differentiate and proliferate. By studying the types of scaffolds produced for various purposes and considering the special properties of the liver, in this project a blend of poly(caprolactone) and chitosan was used as suitable options for the production of liver scaffolds. Solutions of different ratios of the two polymers were prepared and the viscosity and conductivity of the solutions were measured. Viscosity changes are affected by solution concentration and electrical conductivity depending on the presence of chitosan as a polyelectrolyte and both factors affect the final diameter of nanofibers. Fiber morphology and chemical structure were also examined. Fully homogeneous nanofibers were produced with a diameter variation of 50 to 200 nm. FTIR analysis confirms the presence of chitosan in all scaffolds. Quantitative analysis of the spectra also shows that the trend of chitosan change in scaffolds is consistent with the trend of change in solutions. The degradability behavior of scaffolds in phosphate buffer solution was investigated. Morphological changes in structure by FTIR analysis and also confirmation of chitosan exit from the scaffold during degradation using TGA analysis. The degradation process caused some samples to rupture into nanofibers and create ultra-fine fibers. Changes in weight, water adsorption and contact angle, porosity changes, dimensional changes, and mechanical properties were determined at different times of degradation. the highest rate of weight-loss was observed in the first week of degradation. scaffolds with higher levels of chitosan also show higher weight-loss rates. Before degradation, the contact angle of the scaffolds varies depending on the amount of chitosan, but after degradation, it is no longer dependent on chitosan and structural changes on the web are more effective. Porosity changes were investigated by image processing and density methods, both of which showed a decrease in porosity during degradation. All scaffolds show dimensional reduction during degradation. Weight-loss and structural changes and shrinkage cause this behavior. In general, as the amount of chitosan in nanofibers increases, the nanofibers become more brittle and their modulus increases and their strength decreases. Degradation reduces modulus and strength. Also, the behavior of the degraded solution environment was analyzed using pH measurements and showed that little change in pH occurs and will not have a negative effect on the surrounding tissues. The results of degradation were in the neural network and after modeling, the optimum percentage of polymers to produce a suitable scaffold for liver tissue engineering was determined. After reproducing the optimal sample, surface treatment with galactose was performed on it in three different ways. According to SEM, FTIR, and DSC analysis, the presence of galactose in uniform nanofibers was confirmed, which reduces the crystallinity of the scaffold. Based on the contact angle measurement, the presence of galactose increases the hydrophilicity of the scaffold. The highest hydrophilicity is observed in the scaffold that has been modified after electrospinning, which has a contact angle of 82.22 ± 2.2 and has decreased compared to the optimal scaffold (98.52 ± 4.4). according to the results of degradation in phosphate buffer, the highest rate of degradation was observed in this scaffold. By culturing HepG2 cells on the modified scaffolds, and based on the results of SEM and MTT analyzes, it was found that the presence of galactose in the scaffolds increased cell growth and proliferation and was not toxic. The maximum cell viability was 107.73% and was observed in the scaffold that was galactose-containing after electrospinning. Keywords: nanofiber, poly(caprolactone), chitosan, liver tissue engineering, galactose