Drop impact phenomenon plays a remarkable role in a wide range of scientific and industrial applications such as inkjet printing, coating sprays, decreasing water drop erosion in steam turbine blades, agricultural applications in order to increase pesticides’ effect and decreasing soil erosion and even blood spatter analysis in forensic laboratories. In this regard several experimental as well as theoretical and numerical studies have been performed. Due to limitations of experimental and theoretical approaches, recently numerical procedures have been developed broadly for this purpose. Among these methods, multi- body dissipative particle dynamics (MDPD) is an emerging particle based and meso- scale scheme which is appropriate to study multi-phase systems specially liquid-vapor interfaces. With respect to standard Dissipative Particle Dynamics (DPD) method, in MDPD the conservative force consists of two parts: the repulsive force which depends on particle local density and the attractive force which is density independent. Besides, like standard DPD method, dissipative and random forces are used to provide viscous effects and compensate the loss of degrees of freedom due to coarse- graining, respectively. According that MDPD forces are short -range, each particle interacts with those particles which is within a certain radius called cut- off radius. In the present work, MDPD method is applied to simulate the impact of a liquid drop on a solid surface .In order to control the behavior of drop after collision, altering liquid properties by adding small amount of flexible polymers, changing wettability of solid surface from hydrophobic to hydrophilic substrate are investigated. Changing the dynamic characteristic of liquid drop as a result of initial impact velocity is also inquired. In this regard, Newtonian drop and Non- Newtonian drop containing polymer with different concentration of 100, 300, 500 and 1000 ppm are simulated using MDPD method. The Non-Newtonian fluid used here is a low concentration of Poly Ethylene Oxide 300k (PEO) dissolved in the Newtonian liquid which is 1:1 mixture of distilled water and ethylene glycol. Moreover, solid surface has been simulated using freezed DPD particles and the particle penetration into the solid surface is prevented by bounce- back model. To validate the results, dimensionless spreading diameter and dimensionless drop height changes versus dimensionless time are compared with experimental results. In the case of Newtonian drop impact, increasing Weber enhances spreading velocity and consequently reduces spreading time. If Weber goes up to a certain value, splashing phenomenon on solid surfaces with equilibrium contact angle equal or more than 90 o is observed. Additionally, in the case of hydrophobic or super- hydrophobic surfaces, liquid drop rebounds. Adding flexible polymers to the drop increases relaxation time and suppresses contact line velocity during retraction of drop after collision. Thus, for the case that Newtonian drop rebounds, adding merely 100 ppm of PEO polymer decreases retraction velocity and prevents drop rebound. Increasing the wettability of solid surface in collision of both Newtonian and Non- Newtonian drop, indicates the domination of surface effect which suppresses drop retraction and recoiling. Key Words Dissipative Particle Dynamics, Flory Huggins Theory, Micro Drop, PEO Polymer Contained Drop, Drop Impact on a Solid Surface.