Wound healing and management have always been an important challenge for patients, specialists, and physicians. Mostly, wound healing is always associated with wound infection. Therefore, the use of wound dressings plays a significant role in wound healing and prevention of infection. Wound dressings typically replace damaged tissue and create a moist environment conducive to cell migration, resulting in scar tissue. With the advancement of human knowledge, the production of new wound dressings with specific functions is being researched and developed. In this study, ferulic acid was used to modify cotton fabric for application in wound dressings. Ferulic acid is a phenolic acid that, as a natural antioxidant, can react with free radicals. Ferulic acid is slightly reactive with cotton fabrics, so special procedures must be performed to improve this. Cotton fabric was modified in three different methods (two-step cross-linking, pad-dry-cure, and immersion method). Tensile strength, flexural properties, water contact angle, free radical scavenging (antioxidant activity), and antibacterial activity tests were performed on the modified specimens, and The structural properties of the modified samples were investigated by Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FESEM). According to the desired results, these three methods were compared with each other. The results of the tensile strength and flexural properties test showed the appropriate mechanical properties of these samples. The contact angle test results showed the hydrophilicity and suitability of these samples for wound dressing application. Using FTIR, the type of bond between ferulic acid and the cotton fabric was investigated, and their reaction was confirmed. The result of the FESEM test, along with the FTIR-ATR test, showed that ferulic acid penetrated deep into the cotton fabric. According to the obtained results, the antibacterial activity of the modified samples against gram-positive and gram-negative bacteria was also confirmed. The most important test of this study, which was the free radical scavenging test, showed that the modified samples showed high antioxidant properties by decreasing the adsorption intensity at 517 nm and turning the color of DPPH ethanol solution from purple to yellow. According to the studies, no research has been done on modifying cotton fabric with ferulic acid in the application of wound dressings. Keywords: Medical textiles, Wound dressing, Cotton fabric, Ferulic acid, Antioxidant, Antibacterial