Nowadays, threats such as changing land-use and land-cover, climate change, and human activities have increased the vulnerability of natural areas. In recent years, the concept of vulnerability has been used at different locative scales and different fields such as environmental impact assessment and conservation planning. Therefore, vulnerability assessment, especially in ecologically sensitive areas, is necessary. One of these important and sensitive ecosystems is wetland. One of the most important wetlands of the country is the international wetland and Shadegan Wildlife Refuge, which was registered in 1354 as the largest Iran wetland (537700 hectares) and the thirty-fourth of the wetlands of 1201 wetlands registered in the Ramsar Convention List. This wetland is the widest Persian Gulf coastal wetland locating in the southwest of Iran. Its unique and important features are its large size, being natural, habitat diversity, and its role in the local livelihoods. The main problem is that this wetland is being seriously threatened by developmental activities around it, including overuse of water sources in the wetland, urban waste discharge, the fragmentation of the wetland due to the construction of roads, gas and oil piping and industries such as Shadegan Steel and sugar cane industry. So far, a few studies have been done about Shadegan wetland applying the vulnerability approach, and in most studies, only one or two threatening factors have been investigated. However, in this study a set of factors influencing the vulnerability of the wetland in two categories of natural disturbances (drought index, dust storms, land use and land cover change), and human conflicts (distance from roads , developmental points and drainage inputs, population density) have been investigated on the landscape scale. In this study, the monitoring and prediction of land-use and land-cover change in this wetland are done using satellite images, GIS and remote sensing techniques along with the use of the LCM mode in the period from 2001 to 2017 and 2030. The results showed that although in 2017 about 48,000 hectares were added to the water use in the wetland, but by checking and visiting the area it became clear that this increase is due to the entry of drainage and industrial wastewater, such as sugar cane cultivation and regional industry, which is a factor in changing the ecosystem of fresh water to saline water and brackish water. This is resulted in the destruction of herbaceous species of freshwater and replacing it with salty species. In addition, the addition of 38,000 hectares to arid lands proves the inappropriate quality and salinity of the water in the wetland. By reviewing the prediction map for land-use and land-cover in 2030, one could expect that in the future, the size of the water will be reduced, and the salty lands and the arid lands will be increased. Finally, by using the AHP method and using WLC, vulnerability modeling and prioritization of conservation and improvement of the studied area was carried out based on the landscape scale and considering the sensitivity of the region regarding the land-use change (water loss as the main factor of the wetland) in 2017 and 2030. The results showed that the north of the wetland has a priority for improvement and conservation due to the expert opinion and its high importance as a habitat (accumulation of aquatic and endangered birds in that area). Keywords: Landscape, Modeling, Standardized Precipitation Index, Dust Storm Index, Shadegan international wetland, vulnerability