In recent years, some technologies have been developed to increase heat transfer and decrease size in heat exchangers, due to insufficient heat transfer coefficients and high dimensions or costs in them. These technologies have been used widely in chemical and refrigeration industries, cooling process cells, etc. Recently and contemporaneous with emersion of nano technologies, using suspensions of fluids base containing nanoparticles (solid particles with nano-dimensions) have had considerable growth to enhance heat transfer in the heat exchangers. This method has shown that using solid nano-particles into fluids leads to enhanced heat transfer or changed other properties of base fluids. However earlier, increasing heat transfer has been made by change in heat exchanger parameters such as geometries, boundary conditions, fluid type and etc. Also, in addition to using nano-fluids, one can use other methods under research to optimize heat exchanger performance. One of these methods is using sinusoidal pipes in flow direction. Thus, appropriate to modern techniques mentioned above, in this thesis, numerical simulation of heat transfer and flow pressure drop of nanofluids in sinusoidal pipes, were presented. Furthermore, to obtain an optimum case, results of numerical simulation for common fluids and straight pipes, must be compared with results from flow of nanofluids in sinusoidal pipes with different geometris (diameter or amplitude to wave length ratio), various combinations of base fluid and different size and volumetric concentration of nano-particles. In present research, 3D models were created in SolidWorks software and simulations or numerical studies were done in Ansys-Fluent commercial code for nanofluids (including water and ethylene glycol-water as base fluids with and ano-particles) through various straight and simmetric sinusoidal pipes with constant uniform heat flux or constant temperature on the tube wall as thermal boundary condition. Results show that using nano-particles in siusoidal pipe heat exchangers and increase of Reynolds number can affect significant enhancement in heat transfer level. Notwithstanding to this, disadvantages are also often rised up, where the most important item in them is the pressure drop of fluid flow due to presence of solid particles suspensed in the base fluid. So, optimization of volume fraction of these particles is very important in this thesis same as geometry and type of fluid. Keywords : Nanofluid, Sinusoidal tube, Heat transfer, Pressure drop, Performance evaluation criteria (PEC), Constant heat flux Boundary Condition, Constant Temperature Boundary Condition