Today’s textiles are used in various widespread fields of human life in which it is not possible to live without effective use of the textile products. Accordingly, in recent years, textile materials role plays in medical applications as the medical textile products. According to the previous researches, fibrous scaffolds do not have biological and synthetic graft limitations. Hybrid biodegradable polymer scaffolds with composition of nano-microfibers are in great interest of textile structures. This type of hybrid scaffolds benefits mechanical strength and good integrity due to microfibers, and high specific surface water due to nanofibers. The purposes of this research are design, modeling and optimization of bulked yarn for using in hybrid scaffold with fibroin nanofiber coating on yarn, for tendon and ligament scaffold applications. In this study the decision matrix and analytical hierarchy process (AHP) have been used for choosing the suitable yarn for tendon and ligament scaffold. From twisting method, bulked silk yarns were twisted together and were coated with fibroin nanofibers on to surface of final scaffold by electrospinning mechanism. The results of mechanical tests, indicates that the desired mechanical properties of scaffold can be achieved by using bulked silk yarn manufactured by using air nozzle pressure 40 psi and production velocity 80 m/s in final tendon and ligament scaffold structure, while the mechanical behavior of the designed scaffold was very similar to the original tendon of middle-aged people. Keywords: Optimization, AHP, MCDM, Bulked silk yarn, Tendon and ligament scaffold.