Nowdays, most of the researches are focused on metal nano particles. They have unique properties on magnetic, electronic, optical and chemical behavior compared to bulk materials, because of their large surface area to volume ratio. Transition metal nano particles have the high catalytic activites in organic reactions. But the soluble metal nano particles have some problems such as recycling and separation of these catalysts from reactions. To solve this problems it would be better to immobilizethem on suitable support materials and use them as heterogenous catalyst. Therefore, most of current researches and focused on modification of different supports for imobilization of metal nano particles. However, inorganic solids such as silica, carbon, clay and mixed oxides are widely used to carry metal nano particles. Liquid-phase oxidation ofiso propyl aromatic hydrocarbones is a grate scientific technological and commercial importance. In this project, liquid-phase oxidation of 2,6- Diisopropyl naphthalene (2,6-DIPN) to 2,6-Naphthalene dicarboxylic acid (2,6-NDCA) wad studiedwith hetrogenous catalyst immobilization of Co and Mn nano particles on bone and wood and impregnation methods which was promoted by KBr. Also glacial acetic acid was used as solvent. The nano catalyst was prepared from the cobalt nitrate hexahydrate, Co(No3)2.6H2O and manganes nitrate hexahydrate, Mn(No3)2.6H2O, which were immobilized on bone and wood. Different techniques such as BET, SEM, ICP, and TEM were used for characterization of these catalysts. The catalysts showed excellent activity and selectivity.2,6-Naphthalene dicarboxylic acid is building block of special polymers such as polyethylene naphthalate (PEN) that have improved heat resistance, mechanical strength and use in electrical insulation application and can be used for manufacturing food containers for example. Oxidation of 2,6-DIPN redound to produce 2,6-NDCA. Co and Mn are famous and important catalysts for this oxidation reaction but because of high price of theses metals, we were trying to perform this processing whit high yield of 2,6-NDCA whit little amount of Co and Mn. With conversion particles catalyst to particles in nano scale, yield of production 2,6-NDCA became high. With immobilizing Co-Mn in porous of wood and bone, these particles convert to nano particles. In this oxidation reaction KBr was used as a promoter. Oxidation was performed under heat and pressure. 2,6-DIPN (0.86 g), KBr (0.1-0.3 g) and catalyst (0.8 g) were put in the reactor then acetic acid as solvent was added theme. The reactor was adjoined with sources of molecular oxygen. Oxygen (13-17 bar) and heat (150°C -190°C) were exerted in mixture of this reactor. At reaction times of 12 hour at 190°C -200°C and p = 17 bar 2,6-NDCA was formed with high selectivity.