Blasting is one of the main mining operations with the aim of fragmentation and desirable movement rock mass. Have a blasting with proper fragmentation will affect the entire mining operations, reduce mining overall costs and also increase the efficiency of production. In some cases, the unsuitability of the materials dimensions leads to an increase in the cost of crushing and if produced materials use directly, inappropriate grain size is irreparable and may be considered part of the waste materials. Hence, the estimate of rock fragmentation after blasting is significant. Many studies have been done in this regard. The results of these studies to establish empirical methods, Intelligent, statistical, etc., is to predict fragmentation rock. In this study, by using numerical methods, blasting in an explosive block has been simulated. Blasting is a process with high loading speed. Most materials in fast loading show a very different behavior rather than the slow loading. In empirical tests, phenomena that occur during dynamic processes at high speed are often difficult to observe and record. So, the use of numerical methods is helpful in these studies. In the present study, an explosive block of Akdaglar mine has been simulated by using LS_DYNA software. Moreover, Split Desktop software has been used to measure fragment pieces. Results of numerical modeling have been compared with empirical methods including Kuz-Ram, Modified Kuz-Ram, Modified SVEDEFO and Ouchterlony. In the real state, the value of X 50 is 20 cm. In used numerical methods, the value of X 50 with fines and without it, have been estimated 14.3 cm and 21.4 cm respective. Therefore, it is closer to reality in comparison with other empirical methods in this study