Due to many vast application of C- C, C- N, and C- O bond formation in the areas including natural products, herbicides, dyes, agrochemicals, and pharmaceuticals, there has been a great interest in developing new synthetic methods. In this work, a nanocatalyst designed based on Copper (I) Supported on nicotine-fuctionalized Silica was successfully prepared and evaluated as heterogeneous catalysts. Silica-Nicotine-Cu (I) used in C-C (Sonogashira) cross coupling reaction. Good yields and selectivities were observed. The nanocatalyst was investigated by FE-SEM, TEM, XRD and EDX techniques. Cu (I) in a catalyst form spreads on the silica support in nano scale with the average size of 12nm. The Copper amount loaded in the Silica-Nicotine support was measured by ICP technique. The conversions under optimized conditions of using K 3 PO 4 .3H 2 O as base, DMF as solvent were excellent. All the reactions were under conditionand nitrogen atmosphere. In the next part, Fe 3 O 4 -AA-Cu (I) was producted, as the first report and employed in carbon-nitrogen, carbon-oxygen cross coupling reaction, good yield, faster reaction time, and selectivities were observed. This catalytic system showed good activities that were comparable to other copper catalysts used in this field. The desired products were obtained in excellent yields at room temperature within short times in the presence of KOH as optimized base and H 2 O as optimized solvent. The catalyst was characterized by the FT-IR, FE-SEM, TEM, VSM, TGA and xrd techniques