Chamomile is known as an important medicinal plant growing in areas with salinity problems. The soil salinity limits the availability of water and nutrients such as potassium and zinc to plants, thereby, reducing quantity and quality of the crops yield. Considering the roles of potassium and zinc on quantity and quality of plant products in saline conditions and the large area of salt effected soils in the country, this research was conducted to investigate the effects of potassium and zinc on alleviation of the salinity effects on germination, growth and yield, nutrient concentrations, oxidative damage and physiological, biochemical and antioxidant responses of chamomile species (Matricaria chamomilla L.) in a solution culture system. The germination stage experiment as a preliminary test was conducted in laboratory and the main part of the work including vegetative and flowering stages of plant growth was carried out in greenhouse at Soilless Culture Research Center, Isfahan University of Technology. Both experiments were set up as complete randomized factorial design with three factors as salinity, potassium and zinc with three replications. The salt stress was induced using NaCl at four levels 0, 50, 100 and 200 mM for germination stage and four levels 0, 60, 120 and 180 mM for vegetative and flowering stages of plant. The potassium and zinc treatments were 0 and 24 mM KCl , 0 and 16 mM ZnCl 2 for germination stage, 3 and 6 mM KNO 3 , K 2 HPO 4 , 1, 2 and 4 mM ZnSO 4 .7H 2 O for growth stages of plant. Results showed that seeds were not germinated at 200 mM NaCl, also addition of potassium chloride induced negative effects, but zinc had positive effects on seed germination. In vegetative and flowering stages some mechanisms of resistance against salinity such as increase in photosynthetic pigments concentration followd by reduction of leaf area, salt transfer to the lower leaves, excretion of sodium ion, selective absorption, adjustment or osmoregulation with production of organic matter such as proline and uptake of minerals such as potassium, maintenance of higher RWC values and increasing anti oxidant enzymes activity in the plants were introduced. The salinity significantly decreased length of root and shoot in vegetative stage, but increased root dry weight up to 60 mM NaCl in both growth stages. The salinity increased shoot and flower dry weight in flowering stage up to 120 mM NaCl and there was a further increase in the yield parameters due to addition of potassium and zinc. The salinity stress by stimulating the avoidance mechanisms, increased chlorophyll, carotenoids and ion leakage of shoot and root in vegetative stage, while decreased malondialdehyde accumulation in leaves and increased concentration of proline, activity of catalase and peroxidase in both stages of the plant growth. Potassium and zinc treatments by inducing some salinity tolerance mechanisms such as selective uptakes of potassium and iron, maintaining sufficient levels of nutrients required for plants such as potassium and zinc depending on the salinity level and the stage of plant growth, preventing excessive accumulation of Na + followed by decreased concentration malondialdehyde and ion leakage of shoot and root, increasing relative water content, concentration of proline, chlorophyll and carotenoids and engaging section anti oxidant enzymes enhanced tolerance to salt stress in the chamomil plants. Overally, based on the results, although M. chamomilla is known as a plant tolerant to salinity or even as a possible halophyte, nutrition treatments of potassium and zinc in saline condition, could promote the antioxidant properties, alleviate the oxidative damage, enhance yield and the salinity tolerance of this plant.