Iran is one of the arid regions of the world and now faces severe water shortage, so it is necessary to pay more attention to the optimal water usage and protection of water resources. Wheat, as the most important crop in the world, provides the most amount food for the people. Among the factors affecting the yield of wheat production, applying good crop management practices such as appropriate planting date and irrigation results in the efficient harvesting and maximum usage of inputs. In recent years, seed priming treatment has also been considered as a new method in the increasing crop production. In this study, the effects of seed priming with ascorbic acid, planting date and irrigation regime on wheat morpho-physiological and yield were studied. The experiment was conducted as a split factorial design based on a randomized complete block design with three replications during 2016-2017 in a farm located in Shahreza, Isfahan province. The main plots were three irrigation regimes (50, 65 and 80% of drainage moisture of the soil) and the subplots were three planting dates (October 30, November 15 and December 1 st ) and three ascorbic acid rates (zero (control), 200 and 400 ppm). By applying Reduction in water supply, reduced relative water content (17.9%), chlorophyll a (16.9%), chlorophyll b (21.7%), carotenoids (14.7%), membrane stability index (18.8%), weight of 1000 seeds (22.1%), number of seeds per spike (21.4%), plant height (30.1%) and grain yield (29.5%) were decreased. Whereas drought stress increased proline (62.5%), malondialdehyde (39%) and catalase enzyme (71.2%), peroxidase (66.6%), ascorbate peroxidase (71.9%). Delayed in planting date reduced the weight of 1000 seeds (10.8%), number of seeds per spike (10.3%), plant height (14.1%), grain yield (9.6%), chlorophyll a (9%), Chlorophyll b (4.7%), carotenoids (6%), membrane stability index (6.1%), but increased peroxidase enzyme concentration (5.7%), ascorbate peroxidase (11.3%) and proline (62.5%) and malondialdehyde (17.8%). Application of ascorbic acid seed pretreatment increased the weight of 1000 seeds (30.6%), grain number per spike (27.1%), plant height (17.5%), grain yield (16.7%), chlorophyll (10%), chlorophyll b (15.7%), carotenoids (20.6%), relative water content (15.1%) and membrane stability index (15.8%), while reduced catalase enzymes (6.16%), peroxidase (13.1%), ascorbate peroxidase (18%), proline (18.1%) and malondialdehyde (15.1%). The highest yield was achieved at 50% moisture discharge, November 15 as the planting date and priming with 200 ppm with 4987kg/ha yield. The lowest yield was obtained at 80% moisture discharge, 1st December as the planting date and treatment without ascorbic acid with a yield of 2690kg/ha. Based on these results, it can be concluded that application of appropriate planting date, priming with ascorbic acid and managed irrigation improvement in the yield is possible. In addition, the negative effect of drought may be reduced as a result of the seed priming with ascorbic acid by impacting on the physiological characteristics, yield and yield components. Keywords: ascorbic acid, priming, wheat, oxidative stress, drought stress, planting date.