The objective of this study was to estimate the magnitude of the genotype and genotype ×environment interaction effects o safflower yield and other agronomic traits. Fifteen safflower genotypes were tested at six environments (two planting date in three levels of drought stress) in 2015-2016. Combined analysis of variance showed that different environments had significant effect on all traits except days to emergence and days to flowering. Statistical analysis was performed using different stability indexes include wricke ecovalance, shukla stability variance, Eberhart and Russell stability criteria and Additive Main Effects and Multiplicative Interaction (AMMI), superior genotypes were determined based on each method. The stability analysis indicated the presence of two genotypes Mex.295 and Kmp30 showed the lowest wricke ecovalence and shukla stability variance among the high-yielding genotypes. Based on all the stability parameters, Mex.295 genotype was known as the most stable one, because of the higher yield of it rather than mean yield. Kmp30 genotype ranked as a moderate stable genotype because of the lower yield of it rather than mean yield. Mex.111 genotype ranked as the least stable genotype (unstable genotype). According to Eberhart and Russell stability parameters, Mex.295 genotype was identified as the most stable genotype. While IL.111 genotype was known as a genotype with the most adaptation to favorable environment, but the C 111 genotype was identified as a genotype with the least adaptation to unfavorable environmental conditions. The additive main effects) and multiplicative interaction effects analysis (AMMI) showed that the main effects of genotype, environment and genotype × environment interaction were significant. The results of Principal Components Analysis (PCA) showed that the ?rst two PCAs explained 82.51% of the total sum of squares of genotype ×environment variation for ranks of mean grain yield and parameters on the basis of stability. Biplot analysis revealed that genotype Mex.295 due to the least value for genotype ×environment interaction, very little value for IPC1(near zero) and higher yield performance than average, was detected as the most stable and high yielding genotype. The analysis of eight nonparametric statistics showed that Mex.248 genotype have the most stability in term of grain yield under evaluated environments. Finally, with considering the optimal yield and stability of Mex.295 genotype in all studied environments it could be recommended to farmers for plant breeding program in Isfahan region. Key words : Safflower, interaction, Stability analysis, Sustainability Indicators