In this study, magnetic iron oxide nanoparticles as intelligent drug nanocarriers for drug delivery Flufenamic Acid (FFA) , that is an anti-arthritis medicine, was used. For this purpose, first Fe 3 O 4 nanoparticles was synthesized by iron salts with chemical co-precipitation method. Then nanoparticles was coated with Chitosan, PEG and Chitosan/PEG polymers. At the end, FFA drug was absorbed by the coated nanoparticles. In order to characterization synthesized drug carrier, these particles (carriers) were tested by different analysis such as FTIR, FESEM, VSM and fluorescence. By observing and comparing the result of FTIR analysis the successful synthesis of iron oxide nanoparticles and its coating was approved. With FESEM analysis the particles size of Fe 3 O 4 , CS-Fe 3 O 4 , Fe 3 O 4 -CS- PEG4000 and Fe 3 O 4 -CS- PEG6000 were specified respectively 54, 97, 93 and 101 nm. This analysis showed that the particles were synthesized with suitable size (under 100 nm) and they were at the nanoscale.VSM analysis is used to determine the magnetic properties of the nanoparticles and the results showed that high magnetic property of the synthesized nanoparticles.Saturation magnetic properties obtained from this analysis for nanoparticles Fe 3 O 4 , Fe 3 O 4 -CS , Fe 3 O 4 -CS-PEG equal to 60,53 and 46 emu g -1 respectively, which indicates the high amount of magnetic saturation in the synthesized nanoparticles. Reduction of magnetic property after coating demonstrate coating on the nanoparticle.After the characterization of the synthesized nanoparticles, adsorption in vitro (at pH=7.4 T=37 ?C) and drug release FFA experiments, were carried out by UV Spectrophotometer device.X-ray fluorescence analysis (XRF) showed the presence of the drug substance on the surface of coated magnetic nanoparticles. The results of this research showed the use of magnetic nanoparticles can have a significant impact on achieving the targeted drug delivery and controlled release of drugs. Key Words Magnetic nanoparticles, Chitosan , PEG , Nanoparticles, Targeted drug delivery , Controlled release
