: Recently the use of bioceramic coatings on metallic substrates has been developed. Comparing to metallic substrates, bioactive ceramic coatings not only create a more suitable bonding to the bone tissue, but also has an important role in protecting against stresses due to its close elastic modulus to the bone tissue. The objective of this study was to synthesize nanoscale Barium Titanate ceramic, coating Ti6Al4V substrate by it and characterization of coating properties. Barium Titanate nanoparticles were synthesized by using sol-gel process. Transmission Electron Microscope (TEM) pictures showed that the size of the particles are about 20 to 40 nanometers. X-Ray Diffraction Pattern of synthesized powder and applied coatings which were prepared by electrophoresis deposition, indicated that Barium Titanate structure has been achieved. Barium Titanate nanoparticles became suspend in 2-Methoxy Ethanol/Acetyl Acetone solvent and deposition occurred in the optimum time and voltage, which were 5 minutes and 60 volts, respectively. Then the achieved wet coating has been heat treated. In order to evaluate the mechanical properties of coatings, adhesion strength, fracture toughness and nano-indentation tests carried out. Also, samples were immersed in the simulated body fluid (SBF) for certain periods of time for evaluating of biological properties. Measuring the ionic concentration changes in the SBF, elemental analysis and determination of functional groups at the surface of the coatings has been carried out after forming hydroxyapatite depositions. By calculating the length of the radial cracks created by Vickers indenter, coating fracture toughness intended to be 0.145 MPa?m. Maximum adhesive strength has belong to sand blasted sample using coarse sand which achieved 14.6 MPa and the minimum adhesive strength belong to the smoothed sample by emery-paper which achieved 6.2 MPa. The optimum elastic modulus of coating was 24.25 ± 1.7 GPa. Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma spectroscopy (ICP) and scanning electron microscopy (SEM) indicated that bone-like apatite formed on the surface of coatings. Toxicity test results showed that Barium Titanate coating on the Ti6Al4V has no cytotoxicity during 7 days. According to the achieved results, it looks like Barium Titanate coating applied by electrophoresis process can be used as a bioceramic coating for implants. Keywords: Barium Titanate nanoparticles, Sol-Gel, Ti6Al4V alloy, Electrophoretic deposition, nanostructured coatings, bioactivity
