Considering the increasing demand for water and the reduction of available water resources, it is necessary to increase water use efficiency. Using modern irrigation methods and applying irrigation management based on modern scientific principles will increase the efficiency of irrigation. In recent years, extensive agricultural fields in Iran and Isfahan province have been equipped with sprinkler irrigation systems. Therefore, the measurement of wind drift and evaporation losses (WDEL) under the influence of climatic conditions can have useful results in decision making. The purpose of this study were to estimate the wind drift and evaporation losses using weather variables and field measuring the WDEL in selected regions with different climatic conditions. The WDEL at different times (3AM, 6AM, 9AM, 12AM and 15PM) were investigated using two equations at four weather stations (Isfahan, Golpayegan, Fereydounshahr and Najaf Abad) during seve years. Three different cities were selected based o different weather conditions. Then, the amount of WDEL was calculated using three methods including estimation of WDEL using WD1 and WD2 equations, using field measurements and using droplets size in sprinklers WDEL using WD1 and WD2 was estimated according to the days when field measurements were performed. The amount of WDEL in Golpayegan with WD1 and WD2 equations was equals 35.7% and 11.6%, respectively, and it was 18.18% for field measurements and 14.9% for using droplet size method. The amount of WDEL in Najaf Abad was 22.8% and 7.65% for the WD1 and WD2 equations, and it was 12.38% for field measurement and 11% for using droplet size method. The amount of WDEL in Fereydounshahr was 35.76% and 13.39% for WD1 and WD2 equations, respectively, and it was 15.61% for field measurement. and 12.8% for using droplet size method. The results showed that the WDEL has been estimated 2% more than field measurement with WD1 equation and 1.5% less than field measurement by WD2 equation. The correction coefficient for the WD1 equation in the cities of Najaf Abad, Fereydounshahr and Golpayegan was 0.54, 0.44 and 0.51, respectively, and for the WD2 equation was 1.62, 1.17 and 1.56, respectively. There was a significant difference (P 0.05) for WDEL between different hours of day, different days of the year, and different months of the year. Key Words Evaporation and winding losses, Sprinkler irrigation, Droplets size